Origin

Miriam Drew was a woman of French origin who inherited lands at Wundagore Mountain in Transia. She became a scientist and married Jonathan Drew. There she transferred the possession of the Wundagore lands to her husband and and his business partner Edgar Wyndham (High Evolutionary) for them to work there. The trio settled in Wundagore and had a daughter named Jessica (whom would later become Spider-woman). They lived a relative happy life until Jessica became very sick and was given an experimental serum to save her life. During this time, Jessica was comatose and would not recover until she was fully grown into her teenage years. In the meantime, Miriam was killed there by Gregor Russoff, a werewolf.

Later Viper/Madame Hydra would have memories of being Miriam Drew but they were retconned to memory implants courtesy of Chthon.