In an arctic region, explorer Nina Hoffman and her expedition members are caught in a storm. Finding a cave, Nina enters it, seeking warmth. Instead, she finds the Spider-Nation, a race of spider-human hybrids. The Spider Queen chooses Nina to become their champion and transforms Nina into the Webwitch.

Eleven years later, Webwitch is working as a stripper, actively seeking out a male companion to spawn a child that could save the Spider-Nation... and destroy humankind.