Tainted tells the story of George Palmer, a seemingly average white-collar worker with a seemingly average life. When he decides to rent out his childhood home, in an attempt to find closure over the deaths of his sister and parents, he begins to notice a strange smell pervading the property.

George struggles to adjust to his new life, and new tenants - one a young man with a heroin addiction, the other a nurse with a sideline in drug dealing. As events spiral out of his control, George is forced to confront a dark and shameful past, and is pushed to the brink of insanity.