1. Cover by Bob Oksner and Dick Giordano.
2. "Victory is Only 5,000 Centuries Away!" (Supergirl) written by Martin Pasko, penciled by Win Mortimer, inked by Vince Colletta, colored by Tom Ziuko and lettered by John Costanza.
3. "Who's Superman?" A "Mr. & Mrs. Superman" story written by E. Nelson Bridwell, penciled by Kurt Schaffenberger, inked by Frank Chiaramonte, colored by Jerry Serpe and lettered by Milt Snapinn.
4. "Santa's Super-Assistant" A "The Misadventures of Superbaby" story written by Bob Rozakis, penciled by John Calnan, inked by Dave Hunt, colored by Jerry Serpe and lettered by Shelly Leferman.
5. "Reporters are not Born..." (Lois Lane) written by Tamsyn O'Flynn, penciled by Bob Oksner, inked by Vince Colletta, colored by Tom Ziuko and lettered by Milt Snapinn.
6. "The Comic Strip Avenger!" (Jimmy Olsen) written by Paul Kupperberg, penciled by Jose Delbo, inked by Joe Giella, colored by Jerry Serpe and lettered by Ben Oda.
7. "DC Profile #90 Tamsyn O'Flynn" text piece by Michael C. Carmichael.
8. "Hembeck" written, penciled and inked by Fred Hembeck.
9. "Daily Planet" Volume 81 Issue 20 for the month of December 1981 edited by Bob Rozakis, production by Jodi Saviuk and lettered by Typeset. Featuring a Christmas themed edition of The Best of DC #22.

Notes:

• The last issue to feature five stories.
• The last issue to feature the "Daily Planet", "DC Profiles" and "Hembeck".
• The feature "The Private Life of Clark Kent" series was removed and replaced by "The Misadventures of Superbaby" for one issue.
• Daily Star, Batman, Robin, Hocus, Pocus E. Wilbur Wolfingham, Perry White, Jimmy Olsen, Lucille, Susie and George Tompkins, Lana Lang and Lois Lane of Earth-2.
• In the story "Reporters are not Born..." it has a flashback to Superman #153.

Time travel, building contractors on the graft, balloon animals... they could all be hazardous to The Superman Family's health!