Life as Concrete, the title character in one of the most critically acclaimed creator-owned stories in comics history, changes for good in these pages. Recently, former speechwriter Ron Lithgow has been using his high profile as Concrete to promote the population-control agenda of a wealthy CEO. While subjecting himself to a gauntlet of public criticism for Walter Sageman's controversial program, Concrete's back has gone from causing severe itching to causing nausea and painful swelling. What on earth is happening to his body now? And what is this delusional stalker planning to do with a gun?! Meanwhile, aide Larry Munro meets with Astra, his fiancée ... who knows he cheated on her. Following the shock ending of issue #4, this installment changes everything.