Deadpool's quest to beat the rest continues, and this time he's squaring off against the Assassins Guild in the Big Easy!

The Merc with the Mouth's healing factor will get put to the ultimate test when he's pitted against the knife-wielding speedster called HARVESTER!

But even if he's lucky enough to survive that encounter, Deadpool's actions in this very comics mag will align more than one ne'er-do-well against him...and Harvester'll look like a walk in the park!