When a man is mauled to death by abnormally intelligent felines, the mayor of the city hires Luke Cage to investigate the crime! Cage follows a lead and gets attacked by wild cats. With their claws and fangs coated in poison, will the Hero for Hire survive this encounter to solve the mystery? A cat fight unlike any other!

Luke Cage encounters the villain Lionfang. Cage investigates a murder that was caused by three fierce jungle felines, and as it turns out, they are in league with Dr. Alejandro Cortez A.K.A Lionfang.