The Mad Thinker can accurately predict future events down to the tiniest variable, making him one of the most dangerous criminal minds alive. So when it turns out Spider-Man somehow operates outside his calculations, the Mad Thinker must find out why-even if he has to destroy Spidey to do it!

Spider-man foils a number of the Mad Thinker's criminal schemes. Intello is sent to Peter's school to root out Spider-man. Spider-man is captured but escapes the Mad Thinker because his spider-sense is unpredictable by the Mad Thinker's equations.