The worst defeat that Peter Parker ever endured - a moment frozen in the minds of Spider-Man fans everywhere -- was supposed to be far in his past. But now, two villains - ripped, perhaps, directly from that very moment -- have emerged and they threaten to destroy everything that he holds dear.

Mary Jane tells Peter that Norman Osborn is the father. Enraged, Peter destroys their apartments' furniture. Later, a calmer Peter admits Norman has fooled Sarah and Gabe and that he must help them. Their accelerated aging is killing them. And if Spidey doesn't act soon, it could be all over for the twins.