The fate of the 2099 Universe rests on a wager placed between the Abyssus (the terrifying fusion of Knull, God of Symbiotes, and Galactus The Devourer) and Mephisto (Lord of the Underworld)! The two titans have summoned their own teams of combatants to fight to the death for their individual universe's right to survive, with Mephisto summoning fighters from his home 2099 Universe and Abyssus gathering warriors from across the Multiverse.

However, Abyssus doesn't play fair and implanted Knull Seeds among his Abyssal Warriors to fuel their rage and stoke violence! As Knull's Symbiotes corrupt his warriors and drive the 2099 fighters into a corner, only one Abyssal Warrior remains unaffected: Spider-Man 3099. But will the secret of his symbiote resistance provide the leverage the fighters of 2099 need to turn the tides, or is it simply delaying...