The biggest mutant event in a decade continues here! Following the Messiah Complex one-shot, the X-Men scramble to search for the missing mutant newborn. But they’ll need to tackle the Acolytes before they get any answers.

This issue confirms that Neophyte, Vindaloo, Projector, and Gargouille were all not affected by M-Day.

Also included:

Fury's Files. A list of little known facts that Nick Fury kept on the X-Men.

Portfolio Review for New Exiles #1, and "Look Who's Talking!" with Matt Fraction.

Chapter 2

Back at the Xavier Institute for Higher Learning Cyclops reminds Professor X who is now leading the X-Men, and puts Xavier to work with Beast to try to discover why the mutant's powers manifested at birth rather than as a teenager. Cyclops has already dispatched a small group of X-Men to locate a group of former Acolytes to try to discover the location of the Marauders and retrieve the mutant baby from them, and sent Emma Frost to retrieve Madrox, Layla Miller, and Rictor for their own missions. Having temporary erased Madrox's resentment towards the X-Men and desire not to work with them, Madrox and the others agreed to come along. Since losing his powers on M-Day, Rictor would scan as a normal human. For this reason Cyclops wants Rictor to infiltrate the Purifiers to determine their motivation. Madrox and Layla Miller are to locate Forge for details on their own mission.