Guest-starring X-Man! X-Force attempts to prevent Sinister from using Nate Grey for genetic experimentation. It’s Sinister vs. X-Force, with both sides vs. Onslaught! A dizzying battle will ensue!

Synopsis

Domino is all that stands in the way between Mr. Sinister and Nate Grey. Caliban shows up absolutely loses his mind and begin ripping into Mr. Sinister (it is assumed that Apocalypse put a failsafe defense mechanism in Caliban in case Mr. Sinister became a threat). The rest of X-Force and Nate Grey regain consciousness and Domino uses Caliban's diversion as a good excuse to blow up this wing of the Xavier Institute. X-Force is effectively separated from Mr. Sinister.

Outside, Warpath approaches the Xavier Institute and sees the explosion. Much to his surprise, Risque volunteers to join him in finding his friends.

Below the mansion, Caliban and Meltdown find themselves survivors of the explosion. Caliban is ashamed of his wanton attacks against Mr. Sinister. Meltdown feels a bit of compassion and gives him a hug.

Elsewhere, Domino, Sunspot, and Nate Grey realize that Mr. Sinister has shut down Nate's powers, but that Sunspot may be able to help. One of the differences between Nate Grey and Cable is how each was raised. Sunspot just happens to have a treasure trove of Askani teachings in his brain. Nate attempts a mental probe of Sunspot and is flooded by Askani imagery. Despite the psychic backlash, this seems to jumpstart Nate's powers.

Back with Mr. Sinister, the villain has Siryn at his mercy. Shatterstar leaps from the shadows to save her. Mr. Sinister can't help but goad Shatterstar with more mysterious musings on Shatterstar's potential when Warpath and Risque join the fray. Nate then arrives and uses his restored powers to tear into Mr. Sinister. Mr. Sinister begs for a moment to explain his interest in Nate, as he wants to thwart both Apocalypse and Onslaught. He invites Nate to probe his mind for the truth. Nate does, but it is a trap, as Mr. Sinister rechannels the psionic energy back on X-Force. Everyone is knocked out and Mr. Sinister carries Nate's body from the mansion.