Many of the Fables from Fabletown know nothing about Americana. It is revealed that this was intentional--that Mr. Revise, in his mission to leech the magic out of the Mundane world, had destroyed all of the known magical gateways in and out of Americana. However, he missed one powerful gateway, the Great Train. At certain places when the border between the magic world and the real world are "thin", people can jump onto the Great Train and have it take them into Americana.

Jack Horner first discovers the land of Americana and travels there with his friends in order to find a massive treasure that was promised him by Humpty Dumpty. Once there, Jack runs into Hillary Page, who had ventured into the land in search of her father. The groups join up and track down the man who Hillary thinks is her father, a librarian named Bookburner. This ends up being a mistake as not only is Bookburner not her father, but he then decides to hunt down the group with the help of his trackers Natty Bumppo and Slue Foot Sue. The group tries to evade capture but Hillary and Humpty are eventually caught and brought out of Americana. Bookburner discovers what his brother, Mr. Revise, has been doing at the Golden Boughs and decides to wage war on the facility. 

Americana has many diverse regions within its borders, all of which can be reached by the Great Train. Below is a listing of each region and which type of literature or idea that it represents from American Literature.