Raised in the USA, Ernie Colon began his professional career in the late 1960s. Colon worked for publishing house Harvey for twenty years, initially as a lettere, but later as an artist on series like 'Casper the Friendly Ghost', 'Monster in My Pocket' and 'Richie Rich'. His work was also featured in the Warren horror magazines Creepy, Vampirella and Eerie. 

After the folding of Harvey, Colon became a freelancer for other companies. He has worked on many titles like 'Grim Ghost' for Atlas/Seaboard, 'Arak, Son of Thunder' and 'Amethyst, Princess of Gemworld' for DC Comics, 'Airboy' for Eclipse Comics, 'Magnus: Robot Fighter' for Valiant Comics, and 'Damage Control' and 'Doom 2099' for Marvel Comics.  
 
Recently, he was involved in online and digital comics.