After a few unsuccessful attempts at creating a newspaper strip in the late 80’s, Terry Moore decided to follow the lead of indie pioneers like Dave Sim and Jeff Smith by self-publishing a comic book under an imprint he called “Abstract Studios.” That comic book was entitled STRANGERS IN PARADISE and first appeared as a couple of short stories in NEGATIVE BURN. At the time, there was an ongoing feature in NEGATIVE BURN that grabbed Terry’s attention. It was called the ALAN MOORE SONGBOOK. This feature adapted songs that Alan had written for his band in and put them in comic book form, with a different artist illustrating every song. The song that Terry ended up drawing was MADAME OCTOBER, an ambitious rendering of a complicated love story.

STRANGERS IN PARADISE turned out to be a great commercial triumph in the independent comic realm and was published alternately through Abstract and Image for over ten years. Moore received the Eisner award in 1996 for Best Serialized Story for the SIP story collected in the trade paperback "I Dream of You."

In 2007, took over for Sean McKeever as the writer of SPIDER-MAN LOVES MARY JANE for Marvel Comics. It was also in that year that would took over for Joss Whedon as the writer of RUNAWAYS, also from Marvel.

Moore's next self-published series was the 30 issue ECHO, which appeared from March 2008 to March 2011. He then self-published the 42 issue Rachel Rising, which started in August 2011 and concluded in May 2016, followed by the 10 issue Motor Girl, which ran from November 2016 to November 2017. All three series take place in the Strangers in Paradise universe.

He then published Strangers In Paradise XXV in the 25th anniversary of Strangers in Paradise, continued by Five Years, both of which were a crossover between the characters of all the series happening in the Strangers in Paradise universe.

He published the graphic novel Ever: The Way Out in 2020, and is currently writing and drawing Serial, which follows the story of Zoe Mann from Rachel Rising.