The Vermin
The villain, Vermin, was multiplied by Arcade under Kraven the Hunter's orders.
Name:
The Vermin
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First issue:
Origin

Kraven the Hunter was setting up a game hunt for the rich and powerful against the many animal-themed rogues of Spider-Man. He hired Arcade to help him set up the tech, including a contingency if Spider-Man got involved. They kidnapped the villain Vermin, who Kraven also used during he and Spider-Man's most dramatic encounter, and injected him with a serum that caused him to multiply. They were used as a diversion against Spider-Man.
When Kraven's hunt failed, the Vermin escaped into the New York subway system.
Creation
The Vermin first appeared in The Amazing Spider-Man (2018) #20