A futuristic series starring Miguel O'Hara, a geneticist inspired by Spider-Man. In this future, Miguel was a scientist working for a company called Alchemax. In the future, the world is more or less run by corrupt corporations. Miguel developed a process to rewrite a human's genetic code, but then attempted to quit Alchemax, since he was sick of it. The head of Alchemax, Tyler Stone, tricked Miguel into taking a drug called Rapture, which is highly addictive. Miguel knew that he couldn't be a drug addict, so attempted to reset his genetic code so that he wasn't addicted to Rapture. Unfortunately, a jealous colleague altered it so that Miguel had his genetic code reset to that of a spider. And so Spider-Man 2099 was born! The series lasted until issue 46, after which it (and many other 2099 titles) where put together in the "2099: World of Tomorrow" series.

Collected Editions

• Vol. 1 (#1-10)
• Vol. 2 (#11-14 & Annual #1)
• Vol. 3 (#15-22)
• Vol. 4 (#23-33)
• Spider-Man 2099 vs. Venom 2099 (#34-38)
• Spider-Man 2099 Omnibus (#1-46)