Mitsuki was created synthetically by Orochimaru and after many times having his memories erased, finally decided to run away from Orochimaru and live his own life. Unbeknownst to him, this is exactly what Orochimaru wanted him to do, and set him out on the course for Konoha to find and befriend Boruto Uzumaki, for Mitsuki's own sake. After being accepted into the village, Mitsuki graduated the Ninja Academy and formed a team led by Konohamaru Sarutobi with Boruto Uzumaki and Sarada Uchiha.