After the death of X-Corporation: Hong Kong member Risque, the X-Men investigate her assailants the U-Men, a group of humans who forcibly remove organs from mutants to be sold on a black market and reattached to paying recipients. Risque's X-Corporation partner Domino participates in the investigation.

The issue also introduces a new mutant named Xorn who has been imprisoned in a China jail cell for many years. He has a star for a brain, which is contained only by a metal mask he wears at all times. When he decides he wants to commit suicide, which in turn would destroy the entire planet, Cyclops persuades the pacifist mutant to join the X-Men instead.