A group of Shi'ar professional killers. They killed all the members of Jean Grey's family (including her parents) except for Rachel Grey. The Shi'ar sanctioned the murders in order to ensure there would be no new host for the Phoenix force after Rachel would die.

A U.N. affiliated intelligence agency dealing primarily with terrorism and superhuman threats that was originally founded by the U.S. government.

A policing force established by Doctor Doom during his reign over the United States. The director of SHIELD was Jake Gallows; The Punisher.

Anonymous seven member council who conferred with Fury by vidscreen and determined S.H.I.E.L.D. policy and directives.

SHIELD has tried several times to form special teams of super-powered operatives; such efforts have generally ended in failure.

One of the United States' most important espionage agencies; the Secret Headquarters International Reconnaissance, Tactics, and Spies. Both SpyBoy and Bombshell work for this agency.

Shishi are ancient Chinese guardian lions.

Mothra Twins.

The Shock Troop were a group of occult investigators organized by Dr. Druid.

Monsters from the Cthulhu mythos

A technological advanced branch of Yakuza.

A group of humans armed with giant Robots. They called themselves the Shogun Warriors and lived and worked in Japan.

The members of the Shosei Order were mystic guardians of Japan. Mana's family protected Japan's shores for over 800 years. A lineage of Miko priestesses safeguarded Japan from demons, curses, and magical threats over the centuries.

A Native American tribe.

Inhabitants of the planet Sh'pilkuzz, the Sh'pilkuzzians are Larfleeze's people.

S.H.R.E.D. is the elite tactical police force in Dakota City, frequently coming into conflict with the city's many super-powered residents. S.H.R.E.D. stands for Special Heavy-Equipment Rapid Emergency Deployment.

The Shredder Elite were a group of three entities that lived in Foot Clan Headquarters and are villains in Teenage Mutant Ninja Turtles.

Mushroom policemen for the Slug Lord in Las Fungus.

Squadron of Khund warriors reduced in size by Imskian shrink-ray.

Aliens from far far away, and from planet that might be not in our plane of existence.

Siamese twins and acrobats whose skills are so great that they can perform their tricks without ever moving.

An underground group of Russian mutants.

Siberian Death Squad is a group of assassins.

A team of Mel Blanc enthusiasts living in the shattered remains of Pittsburgh.

People with superpowers who don't want to be either superheros or supervillians.

A group of mime themed villians. Who is led by Jessica Mime

Four spirits (Wind, Fire, Blood and Death) that followed the Coyote Kid around. After he died, he became their fifth member, Pain.

The Sidri, also known as Sidrian Hunters, are a hive minded techno-organic alien race and adversaries of the X-Men.

The most sinister secret society extant. An elite group of assassins. This group followed the orders of Fu Manchu.

An alien race in The Manhattan Projects.

Protector of the Jungle Paradise in Black Orchid.

They are a crime syndicate of Hawaii. They pride themselves on fighting on equal terms. If the law carries knives they fight with knives. If the law carries guns they will carry guns. When Superboy came to Hawaii they also raised the stakes.

A criminal organization based out of Platinum Flats who have repeatedly gone head-to-head with the Birds of Prey. Also known as the Metahuman Mafia they hide behind a consortium of companies.

Terrorist organization form by former SHIELD Agents on Earth 65.

The Silver Centurions are a conglomerate of heroes from the 43rd century. They have recruited the Silver Agent and have given him his powers.

Cartoon turned comicbook that attempted to follow the success of ThunderCats. A 65 episode run, allowed for a six book comics series spin-off.

A specialist group of monster hunters for The Order of St. George.

12 beings bestowed the power of the Silver Surfer