"DC Universe" Zero Hour
The villain Monarch gains the power to manipulate time and becomes Extant. He and his mysterious boss try to recreate the universe by eating away at time itself. The heroes of the DC Universe, including alternate and past versions of themselves, must stop Extant and restart time.
"Deadpool" The Deadpool Killogy
Deadpool first goes throughout his Universe to kill and free its enhabitants from the world of fiction. He then kills characters from classic literature to prevent the ideas of the Marvel characters from even starting. He then travels through the Multiverse to kill alternate versions of himself.
"Detective Comics" Bat Murderer
Batman is accused of killing Talia by shooting her in the back. In his hunt for the truth; he encounters her father, Ra's Al Ghul, who claims to be behind it all and not only frames The Dark Knight for her murder, but his as well. He also runs afoul of The Creeper and Sterling Silversmith before resolving the mystery of the smoking gun.