A team of super-villains who came in conflict with the West Coast Avengers. Their powers correlate with the five senses and the "sixth" sense and are agents of the High Evolutionary.

Advanced androids designed to hunt down and eliminate mutants.

The Sentinels of Magic are a magic-aligned group of heroes in the DC Universe.

Following the Decimation of the mutant race, Sentinel Squad O*N*E were commanded by James Rhodes and tasked with policing mutants in the new climate.

Under the leadership of General Grievous, this army of droids fights against the forces of the Republic in the Clone Wars.

A race of near-humans.

Sequids are an alien race with a mindless hive like mentality. They can only exert power when attached to a host.

A type of celestial being in Christianity and Judaism. Usually depicted burning and with multiple wings.

Serenity harbors a crew of nine; three fighters, a Companion, a mechanic, a pilot, a doctor, a preacher and a girl with apparent mental issues. They fly on the edge of the system, keeping out of the Alliance's reach and taking any job they can to keep flying.

A group of powerful entrepreneurs who combined their assets in service of Set.

Snake/human hybrid creatures.

Street gang.

The Serpent Society is an organization of snake-themed supervillains banded together by Sidewinder as he promised they would never be imprisoned, thanks to his power.

A rebranding of the Serpent Society, Serpent Solutions was formed by Jordan Stryke, the first Viper.

A new team made of former Serpent Society members. It is led by Sin, the daughter of the Red Skull. Their goal is to create fear, terror, and agonizing deaths.

A multimillion dollar corporation run by Harrison Snow that sponsors the new X-Factor.

Cloned from the DNA of various super-powered historical figures, the Servants of Darkness became Darkseid's shadow strike force in the 30th century.

Mindless drones of the Infinites which draw energy and mass from surroundings to form limitless numbers.

The robotic henchmen of Doctor Doom.

Seven mutants that have been recruited by Doctor Doom to serve Latveria. Two of them have yet to be revealed by Doom.

The Seven Deadly Sins are the embodiments of the Biblical Seven Deadly Sins of Man.

The Seven Dwarves take Snow White in after a conflict she had with the Queen.

A group belonging to Ra's Al Ghul's League of Assassins.

A parody of the Justice League.

The Seven Soldiers of Victory, also known as Law's Legionnaires, are a team of crime fighters. There had been several incarnations of this team.

A mysterious team from an alternate universe which must keep the fabric of the universe in good form.

Urban legend of crocodiles or alligators, often mutated, which allegedly lives in sewers of various cities.

Police who patrol the Quiet.

The Super Human Advanced Defense Executive.

The Shades are a group of spirits who take over the bodies of humans and expels the original spirits of the humans.

The most terrible being living in the Dreamscape. Shades are the lost souls of Dreamers who died in their sleep, now forever floating through the Dreamscape. They're trying to find a way out that they'll never find.

Also known as United States Hulk Operations was a clandestine U.S. Military organization tasked with hunting down the Hulk and his allies.

A network of informants working for Moon Knight

A clandestine and secretive team of superheroes originally of Milestone Media. Their primary purpose was "to save humanity from itself—no matter what". Very often, this meant amoral cloak & dagger operations and ruthlessly eliminating whatever threats to humanity that they perceived.

Some people who had lost mutant powers on M-Day and were granted Captain Britain-like powers.

A clandestine organization led by Aloysius Thorndrake.

A cover team of heroes who deal with more dark menaces and are used for undercover missions.

Shadow Demons are the elite, hand-picked Thunderers in the Anti-Monitor's forces. Only the most evil of his servants, composed of nearly pure anti-matter, are chosen.

A group of heroes brought together to face Eclipso

Super-powered operatives mutated by US government, fought Spider-Man and X-Factor.

Team of supervillains who once opposed Tommy Monaghan. Sadly, they didn't even had a chance to show their strength.

Paramilitary team of mercenaries, sent against hospitalized foreign ruler, opposed by Scarlet Spider and Strongarm.