The peace-keepers of The Mindscape

Four young misfits are gathered by the original Black Marvel and given identities and powers formerly used by Spider-Man. Although they disbanded early on, they would continue to make appearances individually and from time to time reunite.

Alien race conquered time ago by Thanagarians.

A trio of break-up musicians who were neighborhood hoods. They demanded money.

Spirits of the restless dead in Celtic myth.

Animals from the planet K'ai.

Sluissi were the indigenous reptiles sentient species. Renowned for their ability to repair and maintain starships, were active in galactic society almost since the beginning of the Republic.

Police from Smallville village

S.M.A.S.H. (Supreme Military Agency of Super Humans) is a team composed of gamma-powered superhuman individuals, formed to deal with problems which are too big for the other heroes to smash on. Hulk, his cousin She-Hulk, his ally Rick Jones, newcomer Skaar, and his former enemy Red Hulk form S.M.A.S.H. to fight the threats that nobody else can.

SMASH, or the Society of Modern American Science Heroes, is a super group within Alan Moore's America's Best Comics Imprint. They are contained within the Terra Obscura and Tom Strong comics.

A group of thugs hired by the Mastermind.

A group of Red Skull's followers bent on the destruction of mutantkind.

Inventing firm based in the Land of Ev.

Smog Alert! is a team of bank robbers who wear matching power armor.

Strange creatures who don't have other senses but very enhanced sence smell which allows them to feel their victim even through time and space.

Severed heads suspended in the clouds of nanotechnology that allegedly came from the future. They are the central figures of the Dry Academy sustaining a spell that prevent people from discovering the world's true nature.

Smurfs are small blue fictional creatures which are known to occasionally live in mushrooms. The Smurfs were first introduced in 1958 by Belgian comics artist (Pierre Culliford) in 1958.

The Snake Men are a team of snake-themed villains led by King Hiss. An opposing faction of Snake Men are led by Lady Slither.

Snakeroot is a ninja cult with ties to the Hand, the Chaste, Elektra, Daredevil, and Black Widow.

Their true name, Zn'rx, being unpronounceable these lizard-like aliens were dubbed Snarks. They are the enemies of Earths Power Pack and the Kymellian race.

The Sneepers are an alien race of the Marvel Universe, depicted in the Watcher's tales.

Snowmen live in the snowy mountains of the Third Earth.

The Snow Serpents are the COBRA organizations, arctic troopers.

A criminal group of soccer moms who use their middle-aged rage and mediocre soccer talent to commit crimes. They are foes of the Flaming Carrot.

When Monsieur Mallah and The Brain left the Brother of Evil, the remaining members re-named the team.

Superteam on Earth-20

Advanced androids designed created by a tech company called Solace.

The Soldiers of Misfortune are a group of super-powered individuals that come into conflict with Air Force and the New Warriors.

The Sons of Adam are a terrorist/revolutionary group operating in Kahndaq that opposed the tyrannical rule of Ibac and formed a cult following that revered the ancient warrior Black Adam.

Clones of Damian Wayne born from the body of sperm whales; also known as Heretics.

The sons of Izanami, who most often dwell within her realm, although Susano is also her ambassador.

The Sons of Liberty is a secret American ultra-patriotic paramilitary organization founded by former U.S. Air Force Major Charles Holcroft with the goal of overturning the American government. The organization was the benefactor of its special operative Benjamin Lockwood a.k.a. Agent Liberty.

A white supremacist group led by Hot-streak.

Cult followers of the arch-demon Satannish

A cult of ancient Egyptians who were mutated so that they could not die who worshiped death.